Publications by authors named "J Bizik"
The aim of our study was to monitor the antiproliferative/ cytotoxic and genotoxic effects of both, poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) and titanium dioxide (TiO2) nanoparticles on the tumor (HT-29, MCF-7, U118MG) and healthy (HEK-293T) cell lines during 2D cultivation and during cultivation in the spheroid form (3D cultivation). Cells or spheroids were cultivated with nanoparticles (0.01, 0.
View Article and Find Full Text PDFAccumulated data indicate that inflammation affecting brain structures participates in the development of cancer-related cachexia. However, the mechanisms responsible for the induction and progression of cancer-related neuroinflammation are still not fully understood. Therefore, we studied the time-course of neuroinflammation in selected brain structures and cachexia development in tumor-bearing rats.
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- Pancreatic ductal adenocarcinoma (PDAC) is severely affected by hypoxia due to the presence of excess stroma and a lack of blood vessels, which contributes to its aggressive nature and poor outcomes.
- The study analyzed DNA methylation and gene expression in four PDAC cell lines exposed to different conditions, revealing that certain cell lines were more affected by hypoxia and inflammation.
- Results indicated that while DNA methylation negatively correlates with gene expression, using a DNA methyltransferase inhibitor called decitabine successfully reduced DNA methylation and reactivated silenced genes, highlighting its potential as a therapeutic target in PDAC.
The brain exerts complex effects on the initiation and progression of cancer in the body. However, the influence of cancer localized in peripheral tissues on the brain has been only partially described. Therefore, we investigated gene expression in brain structures that participate in transmitting viscerosensory signals, regulating autonomic functions and food intake, as well as cognition in C57Bl/6J mice with B16-F10 melanoma.
View Article and Find Full Text PDFTumor metastasis is tightly linked with invasive membrane protrusions, invadopodia, formed by actively invading tumor cells. Hypoxia and pH modulation play a role in the invadopodia formation and in their matrix degradation ability. Tumor-associated carbonic anhydrase IX (CAIX), induced by hypoxia, is essential for pH regulation and migration, predisposing it as an active component of invadopodia.
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