This review provides an in-depth summary of the development of anti-cancer drugs for tumor-associated macrophages (TAMs), with a particular focus on the development and tissue specialization of macrophages, and factors influencing the polarization of M1 and M2 macrophages, and mechanistic insights underlying the targeting therapeutic approaches. TAMs, pivotal in the tumor microenvironment, exhibit notable plasticity and diverse functional roles. Influenced by the complex milieu, TAMs polarize into M1-type, which suppresses tumors, and M2-type, which promotes metastasis.
View Article and Find Full Text PDFThe melanoidins formed through the Maillard reaction during thermal hydrolysis pretreatment (THP) of sludge contribute to darkening, refractoriness, and inhibition of effective wastewater and sludge treatment. However, the dynamic production and structural evolution of THP-derived melanoidins are not fully understood. This study aimed to investigate the factors influencing melanoidins production and the associated mechanisms during THP.
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June 2024
Predictive analytics using Electronic Health Records (EHRs) have become an active research area in recent years, especially with the development of deep learning techniques. A popular EHR data analysis paradigm in deep learning is patient representation learning, which aims to learn a condensed mathematical representation of individual patients. However, EHR data are often inherently irregular, i.
View Article and Find Full Text PDFIn 2023, the CO growth rate was 3.37 ± 0.11 ppm at Mauna Loa, which was 86% above that of the previous year and hit a record high since observations began in 1958, while global fossil fuel CO emissions only increased by 0.
View Article and Find Full Text PDFOvercoming acquired resistance to Osimertinib remains a critical challenge in treating NSCLC. This research indicates that Osimertinib-resistant cells exhibit a strong dependence on glutamine metabolism. However, targeting GLS1 shows limited anticancer effects, probably because it cannot fully block the glutamine metabolic pathway.
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