Publications by authors named "J Bertholon"
Article Synopsis
- - The study aimed to compare the effects of different diluent volumes (6 mL vs. 12 mL) on aerosol characteristics and pharmacokinetics of nebulized colistimethate sodium (CMS) for treating ventilator-associated pneumonia caused by multidrug-resistant (MDR) bacteria.
- - Results showed that the 6 mL diluent led to smaller aerosol particle sizes and shorter nebulization times, while pharmacokinetic measures in plasma and urine remained similar across both diluent volumes.
- - The study concluded that using 6 mL for CMS dilution improves nebulization efficiency and stability without negatively affecting drug delivery or absorption in the body.
In previous studies of the smoke from regular cigarettes and water pipes, we measured aerosol particle sizes in three streams; S1, inhaled by the smoker, S2, released by the device itself and S3, exhaled by the smoker. We used an electrostatic low-pressure impactor (ELPI), giving particle size distributions in real time and calculated median diameters, D50, and dispersion (σg). This allowed us to predict airway deposition.
View Article and Find Full Text PDFMarketed since 2004 as an alternative to nicotine delivery and advertised as a valid means to smoking cessation, the electronic (e)-cigarette has been the subject of much controversy but very little experimental study. This review provides a brief summary of the current knowledge of this product. Propylene glycol and glycerol, the main ingredients of the fluid that is vaporized, have proved to be harmless in the fog machines of the entertainment industry.
View Article and Find Full Text PDFBackground: A simple method for effective bronchodilator aerosol delivery while administering continuing continuous positive airway pressure (CPAP) would be useful in patients with severe bronchial obstruction.
Objective: To assess the effectiveness of bronchodilator aerosol delivery during CPAP generated by the Boussignac CPAP system and its optimal humidification system.
Methods: First we assessed the relationship between flow and pressure generated in the mask with the Boussignac CPAP system.
Introduction: Second hand cigarette smoke consists predominantly of nanoparticles (with two dimensions less than 100 nanometres). The aim of this study was to examine the aerosol of cigarette smoke suspended in the air of a smoking room, its disappearance over the course of time, and its retention in the airways of passive smokers, as these processes remain poorly characterised.
Methods: A smoking machine produced cigarette smoke in a room.