Publications by authors named "J Berestecky"
Article Synopsis
- * Researchers developed two types of serological assays in Liberia to assess COVID-19 exposure in four counties, analyzing 189 samples collected in summer 2021.
- * The assays revealed significant exposure to SARS-CoV-2 and other viruses, while also identifying inhibitory antibodies in the samples, which could help improve serological testing capabilities in underrepresented regions.
Article Synopsis
- - Zika virus (ZIKV) is a serious global health threat due to its association with neurological diseases like Guillain-Barré syndrome and microcephaly, and it spreads primarily through mosquito bites.
- - Accurate detection of ZIKV is complicated by its genetic similarity to other flaviviruses and the cross-reactivity of existing monoclonal antibodies (mAbs), particularly those targeting the envelope protein.
- - Researchers have developed two specific mAbs, A11 and A42, which target distinct regions of the ZIKV E protein, enhancing the tools available for research on ZIKV detection and understanding its behavior in infected cells.
Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells modulates tumor cell adhesion, metastasis, and apoptosis. Malignant mesothelioma (MM) is an aggressive neoplasm of the mesothelial cells lining the pleural and peritoneal cavities, and in this study, we found that both human MM tissues and mouse MM cells express high levels of galectin-9.
View Article and Find Full Text PDFFiloviruses such as Ebola virus (EBOV) cause outbreaks of viral hemorrhagic fevers for which no FDA-approved vaccines or drugs are available. The 2014-2016 EBOV outbreak in West Africa infected approximately 30,000 people, killing more than 11,000 and affecting thousands more in areas still suffering from the effects of civil wars. Sierra Leone and Liberia reported EBOV cases in every county demonstrating the efficient spread of this highly contagious virus in the well-connected societies of West Africa.
View Article and Find Full Text PDFIgs in vertebrates comprise equally sized H and L chains, with exceptions such as H chain-only Abs in camels or natural Ag receptors in sharks. In Reptilia, Igs are known as IgYs. Using immunoassays with isotype-specific mAbs, in this study we show that green turtles (Chelonia mydas) have a 5.
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