Pain and psychological stress are intricately linked, with sex differences evident in disorders associated with both systems. Glutamatergic signalling in the central nervous system is influenced by gonadal hormones via the hypothalamic-pituitary-adrenal axis and is central in pain research. Emerging evidence supports an important role for the gut microbiota in influencing pain signalling.
View Article and Find Full Text PDFIo experiences tidal deformation due to its eccentric orbit around Jupiter, which provides a primary energy source for Io's ongoing volcanic activity and infrared emission. The amount of tidal energy dissipated within Io is enormous and has been hypothesized to support the large-scale melting of Io's interior and the formation of a global subsurface magma ocean. If Io has a shallow global magma ocean, its tidal deformation would be much larger than in the case of a more rigid, mostly solid interior.
View Article and Find Full Text PDFBackground: Socioeconomic deprivation has been associated with health inequalities and poor perinatal outcomes. Deprivation is described as a multidimensional concept, with composite indicators (e.g.
View Article and Find Full Text PDFEnteric fever remains a major public health problem in South and Southeast Asia. The recent roll-out of the typhoid conjugate vaccine protecting against S. Typhi exhibits great promise for disease reduction in high burden areas.
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