Publications by authors named "J Ben Keane"

Pain and psychological stress are intricately linked, with sex differences evident in disorders associated with both systems. Glutamatergic signalling in the central nervous system is influenced by gonadal hormones via the hypothalamic-pituitary-adrenal axis and is central in pain research. Emerging evidence supports an important role for the gut microbiota in influencing pain signalling.

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Io experiences tidal deformation due to its eccentric orbit around Jupiter, which provides a primary energy source for Io's ongoing volcanic activity and infrared emission. The amount of tidal energy dissipated within Io is enormous and has been hypothesized to support the large-scale melting of Io's interior and the formation of a global subsurface magma ocean. If Io has a shallow global magma ocean, its tidal deformation would be much larger than in the case of a more rigid, mostly solid interior.

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Background: Socioeconomic deprivation has been associated with health inequalities and poor perinatal outcomes. Deprivation is described as a multidimensional concept, with composite indicators (e.g.

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Article Synopsis
  • - Airway macrophages (AM) are key immune cells in the lungs that help protect against infections, making them important for targeted therapies aimed at enhancing immune responses.
  • - The study investigates how different types of macrophages respond to signaling molecules (IFN-γ and IL-4) that represent immune responses in the lungs, finding that AM rely heavily on glycolysis for their functions, especially in cytokine production.
  • - Results show that AM exhibit unique metabolic responses and functional plasticity compared to monocyte-derived macrophages (MDM), suggesting that AM could be effective targets for new inhaled treatments for lung diseases.
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Enteric fever remains a major public health problem in South and Southeast Asia. The recent roll-out of the typhoid conjugate vaccine protecting against S. Typhi exhibits great promise for disease reduction in high burden areas.

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