Publications by authors named "J Beimler"
Key Points: Patients with AA amyloidosis and age ≥65 years, eGFR <45 ml/min per 1.73 m, and -terminal type-B natriuretic peptide >1000 ng/L and/or type-B natriuretic peptide >130 ng/L at diagnosis have poorer survival. Proteinuria >3.
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- Following kidney transplantation, lifelong immunosuppressive therapy is critical to prevent graft rejection but increases the risk of severe infections, which are a leading cause of death in kidney transplant recipients.
- Torque teno virus load (TTVL) serves as an indicator of immune competence, with low levels linked to higher rejection risks and high levels associated with increased infections in the first year post-transplant.
- A study involving 106 kidney transplant recipients revealed that TTVL dynamics vary over time, notably decreasing after switching medications in patients with BK virus-associated nephropathy and increasing in those receiving high-dose corticosteroid therapy for rejection.
Donor-derived cell-free DNA (dd-cfDNA) identifies allograft injury and discriminates active rejection from no rejection. In this prospective study, 106 kidney transplant recipients with 108 clinically indicated biopsies were enrolled at Heidelberg University Hospital between November 2020 and December 2022 to validate the clinical value of dd-cfDNA in a cohort of German patients. dd-cfDNA was quantified at biopsy and correlated to histopathology.
View Article and Find Full Text PDFBackground: The structured transition of adolescents and young adults with chronic kidney disease (CKD) from pediatric to adult care is important, but data on the time and resources required for the necessary components of the transition process and the associated costs are lacking.
Methods: In a prospective single-center cohort study of 52 patients with pre-transplant CKD (CKD stage 1, n = 10; stage 2, n = 6; stage 3, n = 5; stage 4 and 5, 1 patient each) or kidney transplant recipients (KTR), resource use and costs were evaluated for the key elements of a structured transition pathway, including (i) assessment of patients' disease-related knowledge and needs, (ii) required education and counseling sessions, and (iii) compiling an epicrisis and a transfer appointment of the patient with the current pediatric and the future adult nephrologist.
Results: Forty-four of 52 enrolled patients (84.