Publications by authors named "J Behrens"
Article Synopsis
- The Wnt/β-catenin signaling pathway activation relies on the formation of biomolecular condensates through the polymerization of dishevelled 2 (DVL2).
- Researchers used biochemical techniques to identify oligomeric DVL2 complexes in human cell lines, uncovering a crucial low-complexity region (LCR4) that influences complex formation.
- The study reveals that DVL2's activation of the Wnt pathway is dependent on the interaction of specific regions within the protein, highlighting a two-step process for condensate formation involving both high-affinity and low-affinity interaction sites.
Article Synopsis
- - The Federal Joint Committee (G-BA) requires hospitals to use a geriatric screening tool called GeriNOT during inpatient care, particularly for patients with hip fractures, to identify potential health risks.
- - A study evaluated the effectiveness of GeriNOT on 821 geriatric patients (average age 81), examining their needs for post-inpatient care and risk for readmission, with a focus on different injury types.
- - Results indicated that all groups had GeriNOT scores above the critical threshold, with the hip fracture patients having the highest average score, suggesting higher vulnerability that could benefit from targeted intervention.
Objective: Recombinant adeno-associated virus (rAAV) vectors are powerful tools for the sustained expression of proteins in vivo and have been successfully used for mechanistic studies in mice. A major challenge associated with this method is to obtain tissue specificity and high expression levels without need of local virus administration.
Methods: To achieve this goal for brown adipose tissue (BAT), we developed a rAAV vector for intravenous bolus injection, which includes an expression cassette comprising an uncoupling protein-1 enhancer-promoter for transcription in brown adipocytes and miR122 target sequences for suppression of expression in the liver, combined with packaging in serotype Rec2 capsid protein.
The effects of pelagic trawling on the health and welfare of Atlantic herring (Clupea harengus L.) were investigated on a refrigerated seawater vessel operating in the North Sea. A total of 495 Atlantic herring (Clupea harengus L.
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