Publications by authors named "J Beckers"
Progressive loss of motor neurons is the hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), but the underlying disease mechanisms remain incompletely understood. In this study, we investigate the effects of C21ORF2 mutations, a gene recently linked to ALS, and find that primary cilia are dysfunctional. Human patient-derived mutant C21ORF2 motor neurons have a reduced ciliary frequency and length.
View Article and Find Full Text PDFArticle Synopsis
- Auditing procedures in vocational education aim to enhance educational quality by focusing on compliance with rules while also fostering a development-oriented approach that encourages dialogue and ethical leadership.
- A study involving 1,223 participants from eight Dutch secondary vocational institutions utilized structural equation modeling to explore how auditing influences factors like perceived autonomy, relatedness, trust, and self-efficacy, ultimately affecting intrinsic motivation.
- Results indicated strong positive relationships between model behavior and autonomy, as well as between autonomy and intrinsic motivation, suggesting future research should consider multilevel structures within educational organizations.
Article Synopsis
- Valosin-containing protein (VCP) is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and this study investigates how a mutation in VCP affects mitochondrial function using CRISPR/Cas9 in neuroblastoma cells.
- The mutated cells show enlarged mitochondria with a depolarized membrane potential, leading to increased respiration and heightened activity in the electron transport chain.
- The findings suggest that VCP mutations may cause mitochondrial hypermetabolism through changes in the permeability transition pore (mPTP), impacting mitochondrial function and contributing to disease progression.
New results are presented on a high-statistics measurement of Collins and Sivers asymmetries of charged hadrons produced in deep inelastic scattering of muons on a transversely polarized ^{6}LiD target. The data were taken in 2022 with the COMPASS spectrometer using the 160 GeV muon beam at CERN, statistically balancing the existing data on transversely polarized proton targets. The first results from about two-thirds of the new data have total uncertainties smaller by up to a factor of three compared to the previous deuteron measurements.
View Article and Find Full Text PDFThe COMPASS Collaboration performed measurements of the Drell-Yan process in 2015 and 2018 using a 190 GeV/c π^{-} beam impinging on a transversely polarized ammonia target. Combining the data of both years, we present final results on the amplitudes of five azimuthal modulations, which correspond to transverse-spin-dependent azimuthal asymmetries (TSAs) in the dimuon production cross section. Three of them probe the nucleon leading-twist Sivers, transversity, and pretzelosity transverse-momentum dependent (TMD) parton distribution functions (PDFs).
View Article and Find Full Text PDF