Publications by authors named "J Beck"
Neural cell types have classically been characterized by their anatomy and electrophysiology. More recently, single-cell transcriptomics has enabled an increasingly fine genetically defined taxonomy of cortical cell types, but the link between the gene expression of individual cell types and their physiological and anatomical properties remains poorly understood. Here, we develop a hybrid modeling approach to bridge this gap.
View Article and Find Full Text PDFBackground And Purpose: In patients diagnosed with spontaneous intracranial hypotension (SIH), microspurs are considered the culprit lesion in most ventral dural leaks (type I). The imaging characteristics of discogenic spurs, and their prevalence in the general population has not been reported in the literature.
Materials And Methods: This observational case-control study was conducted comparing the prevalence and characteristics of discogenic microspurs between SIH patients with a type I leak treated at a tertiary hospital between 2013 and 2023 and an age-and sex matched cohort of trauma patients.
Background: Spinal cord injury (SCI) can impair motor, sensory, and autonomic function. The formation of the glial scar comprises protective as well as inhibitory neurite outgrowth properties operated by the deposition of chondroitin sulfate proteoglycans (CSPG). Chondroitinase ABC (ChABC) can degrade CSPG and foster neuroaxonal plasticity as a therapeutic approach to restore locomotor function after SCI.
View Article and Find Full Text PDFArticle Synopsis
- Peripheral nerve blocks (PNBs) are commonly used in pediatric orthopedic surgery for pain management and quicker discharge, but they can lead to both short- and long-term complications.
- A systematic review identified 16 studies (10% of those reviewed) that discussed long-term complications following PNBs in pediatric patients, with 9 reporting issues such as chronic pain, motor deficits, and reduced range of motion.
- Overall, complications were noted in a small percentage of patients, with chronic pain occurring in 5%, strength deficits in 10%, and sensory deficits in just 0.07%.