Optimizing Engagement: Factors Influencing Family Participation in a Positive Parenting Program among Vulnerable Households with Young Children.

This paper addresses a critical gap in family research by examining the risk of families with young children receiving the Minimum Living Income (MLI) in rejecting targeted social interventions, also known as non-take-up (NTU). We analyze recruting process data from the first invitation to participate in a social benefit including the "Growing Happily in the Family-2" program developed in Madrid, Spain, to their written consent prior to its implementation. Measurements of subjective factors reported as reasons for NTU and objective factors of sociodemographic characteristics and detailed household patterns of prior engagement with social services to study NTU response were based on official records and project data.

Pancreatic organogenesis mapped through space and time.

The spatial organization of cells within a tissue is dictated throughout dynamic developmental processes. We sought to understand whether cells geometrically coordinate with one another throughout development to achieve their organization. The pancreas is a complex cellular organ with a particular spatial organization.

Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer.

Triple negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer, whose high frequency of relapse is often due to resistance to chemotherapy. Here, we identify inosine monophosphate dehydrogenase 2 (IMPDH2) as a contributor to doxorubicin resistance, in multiple TNBC models. Analysis of publicly available datasets reveals elevated IMPDH2 expression to associate with worse overall TNBC prognosis in the clinic, including lower recurrence-free survival post adjuvant/neoadjuvant therapy.