Publications by authors named "J Bateson"

Article Synopsis
  • Most lung cancer patients, especially those with EGFR mutations, develop resistance to treatment drugs like osimertinib and gefitinib, often leading to relapse.* -
  • Genome-wide CRISPR screenings pinpointed key resistance pathways, revealing that regulation of the Hippo pathway is a significant factor in this drug resistance among cancer cells.* -
  • Targeting both the Hippo pathway and EGFR together shows promise as a new treatment approach for EGFR mutant lung cancer, potentially improving outcomes for patients.*
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Objective: Silver diamine fluoride (SDF) is an effective non-surgical treatment for dental caries which may also impact oral health-related quality of life (OHRQoL). The objective of this study was to conduct a network meta-analysis of SDF versus other standard of care therapies on OHRQoL.

Data Sources: Studies published in PubMed/MEDLINE, Scopus, or Web of Science through July 2021 with no date or language restrictions.

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Multivalent second-generation TRAIL-R2 agonists are currently in late preclinical development and early clinical trials. Herein, we use a representative second-generation agent, MEDI3039, to address two major clinical challenges facing these agents: lack of predictive biomarkers to enable patient selection and emergence of resistance. Genome-wide CRISPR knockout screens were notable for the lack of resistance mechanisms beyond the canonical TRAIL-R2 pathway (caspase-8, FADD, BID) as well as p53 and BAX in TP53 wild-type models, whereas a CRISPR activatory screen identified cell death inhibitors MCL-1 and BCL-XL as mechanisms to suppress MEDI3039-induced cell death.

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Article Synopsis
  • New therapeutic targets for oral squamous cell carcinoma (OSCC) are needed, leading to genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines mainly from Asian sources to find genetic weaknesses.
  • Researchers identified both known and novel fitness genes, revealing that many previously studied OSCC-related genes might not be crucial for treatment while some other fitness genes show promise as potential targets.
  • A particular dependency on YAP1 and WWTR1 from the Hippo pathway was validated, and OSCCs with a WWTR1 dependency showed better responses to immunotherapy, highlighting the genes' potential for targeted treatment.
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Background: The COVID-19 outbreak has placed the National Health Service under significant strain. Social distancing measures were introduced in the UK in March 2020 and virtual consultations (via telephone or video call) were identified as a potential alternative to face-to-face consultations at this time.

Local Problem: The Royal National Orthopaedic Hospital (RNOH) sees on average 11 200 face-to-face consultations a month.

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