Autonomous Defense Based on Biogenic Nanoparticle Formation in Daunomycin-Producing .

Daunomycin is a chemotherapeutic agent widely used for the treatment of leukemia, but its toxicity toward healthy dividing cells limits its clinical use and its production by fermentation. Herein, we describe the development of a specialized cultivation medium for daunomycin production, including a shift to oil rather than sugar as the primary carbon source. This achieved an almost threefold increase in daunomycin yields, reaching 5.

Impact and Durability of the Affordable Care Act Medicaid Expansion on Lung Cancer Treatment.

Background: Medicaid expansion began in 2014 after passage of the Affordable Care Act; however, the impact and durability of the effects on lung cancer treatment utilization are poorly defined. We aimed to determine whether there is a persistent difference in utilization of lung resection, lung biopsy, and nonoperative treatment of lung cancer in states participating in Medicaid expansion compared with states that are not.

Methods: A retrospective cohort study was completed analyzing the difference in utilization between Medicaid expansion states and non-expansion states in 2012-2013, 2016-2017, and 2019.

The Daunomycin: Biosynthesis, Actions, and the Search for New Solutions to Enhance Production.

Daunorubicin (DNR) is an anthracycline antibiotic originating from soil-dwelling actinobacteria extensively used to treat malignant tumors. Over the decades, extensive attempts were made to enhance the production of anthracyclines by introducing genetic modifications and mutations in combination with media optimization, but the target production levels remain comparatively low. Developing an appropriate culture medium to maximize the yield of DNR and preventing autotoxicity for the producing organism remains a challenge.

Production and properties of particleboard and paper from waste poppy straw.

Due to the scarcity of wood in some countries, it is necessary to replace it with other raw materials and at the same time use the waste material. The aim of this research is to use poppy waste straw for the efficient conversion of possible lignocellulosic materials - pulps and particleboards. Their suitability for the production of composites is assessed on the basis of selected physical or mechanical properties.