A comparative study of cefaclor vs. amoxicillin/clavulanate in tonsillopharyngitis.

Background: Acute pharyngotonsillitis (APT) is one of the most common inflammatory processes of adults and children in an outpatient setting. Increasing failure rates, hypersensitivity to penicillin, the required multiple daily doses and common side effects lead to poor patients compliance and thus inadequate treatment duration, providing therefore ground for considering alternative antimicrobial agents.

Material And Methods: This multicenter, randomized, single blind study was undertaken in order to compare efficacy and safety of cefaclor (375 mg BID) and amoxicillin/clavulanate (625 mg BID) in 10 days treatment regiment of ambulatory patients with APT.

[Examination of reaction time--auditory brainstem responses--ABR in noise induced temporary and permanent threshold shift].

This study was conducted to investigate the differences between auditory brainstem responses--ABR recorded in men with temporary or permanent threshold shifts (TTS or PTS). Behaviorally, the tested ears showed insignificant differences in the hearing thresholds at frequencies in the range 0.25-8 kHz.

[Changes induced by auditive monoaural and binaural fatigue in TTS and the auditory brainstem response latency].

The purpose of the research was to study the TTS values and latency of fifth wave Auditory Brainstem Response in human monaural and binaural fatigue, using auditory evoked potentials. From the results obtained in 12 volunteers, it is concluded that during exposure to auditory fatigue, if only one ear is protected, the unprotected ear is subject to a greater hearing loss than would be expected with both ears unprotected. The practical implication of these conclusions is that subjects with unilateral hearing loss occupationally exposed to noise run a greater risk for the healthy ear than subjects with normal hearing.