Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system and is widely recognized as a disease primarily affecting women. The relationship between MS and hypogonadism is complex and not fully understood, with recent evidence showing that hypogonadism may have a significant impact on the quality of life and disease progression of patients with MS.
Objectives: This review aims to provide an overview of the current knowledge regarding the relationship between MS and hypogonadism, including the mechanisms underlying this relationship; the effects of hypogonadism on patients with MS; and the potential benefits and drawbacks of testosterone replacement therapy for patients with MS and hypogonadism.
Eur Heart J Qual Care Clin Outcomes
November 2023
Proc Natl Acad Sci U S A
March 2019
Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme. Mutations in and aberrant function of UCHL1 have been linked to many neurological disorders. UCHL1 activity protects neurons from hypoxic injury, and binding of stroke-induced reactive lipid species to the cysteine 152 (C152) of UCHL1 unfolds the protein and disrupts its function.
View Article and Find Full Text PDFNutr Clin Pract
February 2006
Central venous catheters (CVCs) are commonly used to deliver a variety of therapies such as chemotherapy and parenteral nutrition. It is well known that there are complications associated with CVCs; a major complication is catheter-related bloodstream infection (CRBSI). Many strategies exist to prevent CVC complications and CRBSI.
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