Effects of antiarrhythmic drugs in the isolated papillary muscle preparation of the guinea-pig.

Antiarrhythmic effects of a series of N-substituted derivatives of 2-amino-2-methylpropanol were studied using isolated papillary muscle preparation of guinea-pig heart in order to evaluate the chemical structure--biological activity relationship. All tested drugs were found to belong to the 1st group of antiarrhythmic agents characterized by the depression of normal electrophysiological properties of the heart muscle cell. The most active compounds were phenylethyl and p-bromophenylethyl derivatives, the effects of which were comparable with those of quinidine.

Preliminary screening of anticholinergic effect of some new derivatives of glycolic and aminoacetic acids.

The anticholinergic effect of some new alkylaminoalkyl esters of benzilic, cyclohexyl, 1-hydroxycyclohexyl, piperidino-and morpholino acetic acids (Table 1) was evaluated. Only benzilic acid esters were active and the 2-N-piperidinoaminoethyl benzilate hydrochloride (ANC-30) has the highest pA2 value.

Preliminary screening of anticholinergic effect of new 1,3-dioxolane and 1,3,-dioxane derivatives.

Some of the 28 investigated new derivatives show distinct anticholinergic activity. The greatest activity, that of 2-cyclohexyl-2-phenyl-5-piperidinodioxane-1,3 was greater than of the atropine sulfate.

Effect of ethanol on subcellular metal distribution in rat liver.

The effect of ethanol on the subcellular distribution of Mn, Cu, Zn, Mg and Cr in rat liver has been investigated. Significant changes in Mg, Zn and Mn distribution have been observed. No change in the microsomal Mn, Cu, Zn, Mg and Cr content has been found.