Lipoprotein lipase gene mutations in coronary artery disease.

Background: Genetic lipoprotein disorders are frequently associated with premature coronary artery disease (CAD). Functional mutations of the lipoprotein lipase (LPL) gene are associated with altered plasma lipoprotein profiles and are relatively common in French Canadians.

Objective: To investigate the prevalence of LPL gene mutations in a group of patients with premature CAD and in a healthy control group.