Publications by authors named "J Bahl"

In North America, raccoon rabies virus (RRV) is a public health concern due to its potential for rapid spread, maintenance in wildlife, and impact on human and domesticated animal health. RRV is an endemic zoonotic pathogen throughout the eastern USA. In 1991, an outbreak of RRV in Fairfield County, Connecticut, spread through the state and eventually throughout the Northeast and into Canada.

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Background: Older adults often mount a weak immune response to standard inactivated influenza vaccines. To induce a stronger response and better protection, a high-dose (HD) version of the inactivated Fluzone vaccine is recommended for individuals >65 years of age. While better immunogenicity and protection against the vaccine strain has been shown, it is not known if the HD vaccine also induces a robust antibody response to heterologous strains.

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The response to COVID-19 altered global dispersal of influenza viruses.

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Article Synopsis
  • The study introduces NIAViD, an unsupervised machine learning tool that effectively detects antigenic changes in H3N2 influenza A viruses, which is crucial for improving vaccine design.
  • NIAViD achieved a sensitivity of 88.9% in training and 72.7% in validation, significantly outperforming a standard model, while eliminating the need for costly laboratory assays.
  • This tool enhances influenza surveillance by identifying new antigenic clusters and pinpointing critical sites for antigenic changes, ultimately helping in the development of more effective vaccines.
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Influenza A/H9 viruses circulate worldwide in wild and domestic avian species, continuing to evolve and posing a zoonotic risk. A substantial increase in human infections with A/H9N2 subtype avian influenza viruses (AIVs) and the emergence of novel reassortants carrying A/H9N2-origin internal genes has occurred in recent years. Different names have been used to describe the circulating and emerging A/H9 lineages.

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