Circulating cytokine associations with clinical outcomes in melanoma patients treated with combination nivolumab plus ipilimumab.

Nivolumab plus ipilimumab (aCTLA-4/aPD-1) combination therapy has significantly improved clinical outcomes in patients with metastatic melanoma, with 50%-60% of patients responding to treatment, but predictors of response are poorly characterized. We hypothesized that circulating cytokines and peripheral white blood cells may predict response to therapy and evaluated 15 cytokines and complete blood counts (CBC with differentials) from 89 patients with advanced melanoma treated with combination therapy from three points in time: pre-treatment, one month and approximately three months after starting therapy. Clinical endpoints evaluated included durable clinical benefit (DCB), progression-free survival (PFS), and overall survival (OS).

Memristors with Monolayer Graphene Electrodes Grown Directly on Sapphire Wafers.

The development of the memristor has generated significant interest due to its non-volatility, simple structure, and low power consumption. Memristors based on graphene offer atomic monolayer thickness, flexibility, and uniformity and have attracted attention as a promising alternative to contemporary field-effect transistor (FET) technology in applications such as logic and memory devices, achieving higher integration density and lower power consumption. The use of graphene as electrodes in memristors could also increase robustness against degradation mechanisms, including oxygen vacancy diffusion to the electrode and unwanted metal ion diffusion.

Perspective on solving the problem of declining interest in physical activity in Poland.

One of the leading areas of Polish research addressed in the physical culture sciences, is the declining interest in physical activity. The likely reason for this situation may be the inadequate communication of physical culture to today's generations: BB (baby boomers), X (great unknowns), Y (millennials), Z (snowflakes), Alpha (digital). Therefore, the aim of this article is to address the problem of declining interest in physical activity in Poland by identifying the appropriate approach of teachers, trainers and instructors to today's generations.