Moisture measurement: a new method for monitoring freeze-drying cycles.

Quality of the final product largely depends on the freeze-drying process. In turn this largely depends on an adequate control of the amount of residual moisture after freeze-drying. Measuring this amount in the chamber of the freeze-dryer to determine the end point of sublimation and the end point of secondary drying provides a reliable control with regard to the methods traditionally used (for example rapid increase in product temperature).

Antigenic variations of Candida albicans in vivo and in vitro--relationships between P antigens and serotypes.

Serum samples from patients with candidosis and from rabbits experimentally infected with serotype B C. albicans strains consistently showed higher antibody titers against Candida strains with serotype A antigens than strains with serotype B antigens, in indirect fluorescent antibody tests. When sera from rabbits infected with C.

Endoprotease in Plasmodium yoelii nigeriensis.

1. P. yoelli nigeriensis has an acid endoprotease (cathepsin D) and an endoarylamidase.

[Interaction of chloroquine with ferriprotophorphyrin IX. Nuclear magnetic resonance study].

Chloroquine is still the antimalarial drug which is the most utilized. Nevertheless the molecular mode of action of this drug is not very well understood. When mouse erythrocytes injected with Plasmodium berghei are exposed to chloroquine, the first biochemical event is rapid accumulation of the drug.

[Ultrastructural and cytochemical aspects of regenerating "Candida albicans" sphero-protoplasts (author's transl)].

Subcellular modifications associated with sphero-protoplast regeneration of Candida albicans were followed with the electron microscope. After 30 min of regeneration the ultrastructural study revealed a considerable proliferation of plasmalemma invaginations and an abundant synthesis of glycogen in association with an extension of the Golgi apparatus/endoplasmic reticulum system. Later, the inflection of these invaginations and their fusion with the plasmalemma lead to a rejection of cytoplasmic areas in the cell wall.