Publications by authors named "J B Wilk"
Waste produced during cultivation of edible plants can be a valuable source of bioactive molecules. Herein, we present the valorization of tomato leaves to obtain biologically active extracts. Deep eutectic solvents (DESs), composed of natural ingredients, were applied as extracting solvents.
View Article and Find Full Text PDFRecently, we reported on the simple, scalable synthesis of quantum-confined one-dimensional (1D) lepidocrocite titanate nanofilaments (1DLs). Herein, we show, using solid-state UV-vis spectroscopy, that reducing the concentration of aqueous 1DL colloidal suspensions from 40 to 0.01 g/L increases the band gap energy and light absorption onset of dried filtered films from ≈3.
View Article and Find Full Text PDFA computational tool to optimize clinical trial parameter selection in Duchenne muscular dystrophy: A practical guide and case studies.
CPT Pharmacometrics Syst Pharmacol
November 2024
Article Synopsis
- * A new clinical trial simulator (CTS) has been developed using five models that track changes in functional test performances, offering a way to optimize trial parameters and endpoints for DMD studies.
- * This report illustrates the CTS’s functionality through two case studies, showcasing how it can enhance trial design while maintaining statistical significance, ultimately preventing unnecessary increases in trial size and duration.
Article Synopsis
- Heart failure (HF) is a serious condition where the heart fails to pump enough blood, leading to poor organ function and fluid accumulation.
- Recent research highlights the role of microRNAs (miRNAs) in regulating gene expression related to HF, implicating specific miRNAs like miR-30d and miR-126-3p in heart function and remodeling.
- Understanding both traditional biomarkers (like natriuretic peptides and troponins) and newer diagnostic methods can enhance the management of HF and its impact on other organs like the kidneys and liver.