Comparison Between Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite and Autogenous Bone Graft in Bone Regeneration Applications: Biochemical Mechanisms and Morphological Analysis.

It was assumed that only autogenous bone had appropriate osteoconductive and osteoindutive properties for bone regeneration, but this assumption has been challenged. Many studies have shown that synthetic biomaterials must be considered as the best choice for guided bone regeneration. The objective of this work is to compare the performances of nanohydroxyapatite/β-tricalcium phosphate (n-HA/β-TCP) composite and autogenous bone grafting in bone regeneration applications.

Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging.

Background: The aging of the skin, particularly around the periorbital region, is a complex process characterized by the accumulation of senescent cells, decreased collagen production, and reduced skin elasticity, leading to visible signs such as fine lines, wrinkles, and sagging.

Objective: This study investigates the efficacy of a novel topical formulation, OS-01 EYE, containing the senomorphic peptide, OS-01, along with other active ingredients, in improving the skin around the eyes.

Methods: A 12-week clinical study was conducted with 22 participants who applied OS-01 EYE twice daily.

Harnessing nature's palette: Exploring photosynthetic pigments for sustainable biotechnology.

Photosynthetic microorganisms such as cyanobacteria, microalgae, and anoxygenic phototrophic bacteria (APB) have emerged as sustainable and economic biotechnology platforms due to their ability to transform energy from light into chemicals through photosynthesis. The light is absorbed by photosynthetic pigment-protein antenna complexes which are composed of pigments such as bacteriochlorophylls (BChl) and carotenoids in APB, and chlorophylls (Chl), phycobiliproteins (PBP), and carotenoids in cyanobacteria and microalgae. These photosynthetic pigments are essential in the physiology of photosynthetic microorganisms and offer significant health benefits due to their potent antioxidant activity, with properties that include anticancer, antiaging, antiproliferative, anti-inflammatory, and neuroprotective effects.

Psychological and interpersonal dimensions of sexual function and dysfunction: recommendations from the fifth international consultation on sexual medicine (ICSM 2024).

Introduction: Sexual health concerns are common and significantly impact quality of life, but many people do not seek treatment due to embarrassment and other barriers. A biopsychosocial model of assessment and treatment acknowledges the biological, psychological, and social contributors to sexual difficulties and suggests that all these domains should be evaluated.

Objectives: This paper provides an overview of the major psychological factors contributing to sexual difficulties and offer an evidence-based approach for primary care clinicians to assess and treat these issues.