Kinematics and kinetics of dogs walking over increasing heights of cavaletti exercise.

The purpose of this study was to identify the effects of four heights of cavaletti exercise on canine kinematics and kinetics. Eight dogs had kinematics and kinetics data collected whilst completing cavaletti pole exercises at four different heights (floor, mid-metatarsal, hock, and stifle). Dogs had anatomical markers placed on bony landmarks of the fore and hindlimb joints.

The Primacy of Adipose Tissue Gene Expression and Plasma Lipidome in Cardiometabolic Disease in Persons With HIV.

Background: Persons with HIV (PWH) on contemporary antiretroviral therapy (ART) are at elevated risk for developing age-related cardiometabolic diseases. We hypothesized that integrative analysis of cross-tissue, multimodal data from PWH could provide insight into molecular programming that defines cardiometabolic phenotypes in this high-risk group.

Methods: We enrolled 93 PWH without diabetes who were virologically suppressed on contemporary ART and obtained measures of insulin resistance, glucose intolerance, and adiposity.

A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver.

Hepatic steatosis is a central phenotype in multi-system metabolic dysfunction and is increasing in parallel with the obesity pandemic. We use a translational approach integrating clinical phenotyping and outcomes, circulating proteomics, and tissue transcriptomics to identify dynamic, functional biomarkers of hepatic steatosis. Using multi-modality imaging and broad proteomic profiling, we identify proteins implicated in the progression of hepatic steatosis that are largely encoded by genes enriched at the transcriptional level in the human liver.

A micropore nanoband electrode array for enhanced electrochemical generation/analysis in flow systems.

Our previous work has established that micron-resolution photolithography can be employed to make microsquare nanoband edge electrode (MNEE) arrays. The MNEE configuration enables systematic control of the parameters (electrode number, cavity array spacing, and nanoelectrode dimensions and placement) that control geometry, conferring a consistent high-fidelity electrode response across the array (, high signal, high signal-to-noise, low limits of detection and fast, steady-state, reproducible and quantitative response) and allowing the tuning of individual and combined electrode interactions. Building on this, in this paper we now produce and characterise a micropore nanoband electrode (MNE) array designed for flow-through detection, where an MNEE edge electrode configuration is used to form a nanotube electrode embedded in the wall of each micropore, formed as an array of pores of controlled size and placement through an insulating membrane of sub-micrometer thickness.

Abdominal Compared With Coronary Artery Calcification and Incident Cardiovascular Events and Mortality in Black Adults.

Background: Black adults show heightened cardiovascular risk compared with other groups despite comparable or lower coronary artery calcium (CAC) scores, indicating potential cardiovascular risk underestimation by CAC. Abdominal aortic calcification (AAC), preceding CAC, may predict cardiovascular events better in Black adults who are prone to early atherosclerotic cardiovascular disease and excess events at low CAC scores.

Methods: We included 2551 participants from the JHS (Jackson Heart Study) visit 2 examination (2005-2008) without cardiovascular disease, followed through 2016.