Publications by authors named "J B Starzyk"
The use of adeno-associated viruses (AAVs) as donors for homology-directed repair (HDR)-mediated genome engineering is limited by safety issues, manufacturing constraints and restricted packaging limits. Non-viral targeted genetic knock-ins rely primarily on double-stranded DNA (dsDNA) and linear single-stranded DNA (lssDNA) donors. dsDNA is known to have low efficiency and high cytotoxicity, while lssDNA is challenging for scaled manufacture.
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- - The study investigated ovarian reserve (OR) in reproductive-aged women with autoimmune thyroid disease (ATD) to determine the optimal time for assessment, involving 70 ATD patients and 29 controls.
- - Measurements included hormones such as AMH, FSH, and Inhibin-B, primarily taken during the early days of their menstrual cycle.
- - Findings suggest that euthyroid girls and young women with ATD generally have normal OR, indicating routine OR evaluation may not be needed for this group, while those with hypothyroidism should still be assessed.
FlexPoints: Efficient electrocardiogram signal compression for machine learning.
J Electrocardiol
January 2025
The electrocardiogram (ECG) stands out as one of the most frequently used medical tests, playing a crucial role in the accurate diagnosis and treatment of patients. While ECG devices generate a huge amount of data, only a fraction of it holds valuable medical information. To deal with this problem, many compression algorithms and filters have been developed over the years.
View Article and Find Full Text PDFThyroid cytology in pediatric patients: a single-center study from 2015 to 2023-is there a necessity for distinct treatment approaches for patients with and without autoimmune thyroiditis?
Virchows Arch
November 2024
The management of thyroid nodules is guided by the cytological classification provided by The Bethesda System for Reporting Thyroid Cytology. Notably, the biology of thyroid tumors in pediatric patients differs from that in adults, and there is limited research focused on pediatric cases. This study aimed to assess the effectiveness of the Bethesda system in pediatric patients treated at the largest tertiary pediatric thyroid center in Poland between 2015 and 2023.
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- Congenital adrenal hyperplasia (CAH) results from genetic disorders affecting steroid hormone production, with P450scc enzyme being critical for converting cholesterol to pregnenolone; its deficiency leads to hormone shortages.
- A specific case report details a patient with CAH due to P450scc deficiency, characterized by complete 46, XY sex reversal, distinct facial features, and limbs that are shorter than normal; this case seems to be the first recorded in Poland.
- The study concludes that CYP11A1 deficiency is uncommon and leads to primary adrenal insufficiency with diverse sexual development disorders, emphasizing the need for specialized management and potential surgery to reduce risks associated with abnormal gonadal tissue.