Publications by authors named "J B Slingerland"
Tumor-initiating cancer stem cells (CSC) pose a challenge in human malignancies since they are largely treatment resistant and can seed local recurrence and metastasis. Epigenetic mechanisms governing cell fate decisions in embryonic and adult stem cells are deregulated in CSCs. This review focuses on the methyltransferase DOT1L, which methylates H3K79 and is a key epigenetic regulator governing embryonic organogenesis and adult tissue stem cell maintenance.
View Article and Find Full Text PDFTopology in many-body physics usually emerges as a feature of equilibrium quantum states. We show that topological fingerprints can also appear in the relaxation rates of open quantum systems. To demonstrate this we consider one of the simplest models that has two topologically distinct phases in its ground state: the Kitaev chain model for the p-wave superconductor.
View Article and Find Full Text PDFChimeric Antigen Receptor (CAR) T cells targeting CD19 induce durable remissions in patients with relapsed or refractory non-Hodgkin lymphoma (NHL), but many patients experience treatmentrelated toxicity. Cytokine release syndrome and immune effector cell-associated neurologic syndrome are extensively characterized. However, limited data exist on the burden, predictors, and implications of acute kidney injury (AKI) after CAR T cell therapy.
View Article and Find Full Text PDFArticle Synopsis
- Intestinal microbiota plays a crucial role in various diseases, and understanding diet's impact on it is essential for developing targeted therapies.
- A study analyzing meals and stool samples from 173 hospitalized patients found that higher caloric intake is linked to greater fecal microbiota diversity.
- The research indicates that consuming sweets or sugars while on antibiotics may disrupt the microbiome, suggesting that reducing sugar intake during such treatment could help protect gut health.
Article Synopsis
- Research shows a correlation between the gut microbiome and the effectiveness of cancer immunotherapy, specifically for CAR T cell patients.
- The study identifies pentanoate, a metabolite from commensal bacteria, as a key factor that enhances patient survival by improving CAR T cell performance in challenging tumor environments.
- Findings suggest that incorporating microbial metabolites like pentanoate into CAR T cell manufacturing can exploit metabolic pathways and epigenetic changes to enhance treatment outcomes.