Chemical proteomic profiling reveals prostaglandin termination enzyme PTGR2 as a key molecular target of natural coumarin fraxetin.

Natural coumarins represent a diverse group of secondary metabolites with a wide range of biological activities. However, their specific molecular targets have remained largely unexplored. Employing chemical proteomics, a comprehensive analysis of the protein targets of the natural coumarin fraxetin has been conducted.

Understanding the Needs of Young and Middle-Aged Chinese People Who Have Experienced a Stroke Who Have Not Successfully Returned to Work: A Qualitative Study.

Objectives: The study aims to understand the return to work (RTW) needs of young and middle-aged people who have experienced a stroke and to contribute to the development of supportive RTW services.

Design: A qualitative study employing the phenomenological method.

Participants: Eleven young and middle-aged people who have experienced a stroke participated in the study.

Isolated Tin Enhanced CO Coverage-Regulation on SnCu Alloy for Selective CO Electroreduction to C Products.

Electricity-powered C─C coupling of CO represents an attractive strategy for producing valuable commodity chemicals with renewable energy, but it is still challenging to gain high C selectivity at high current density. Here, a SnCu single-atom alloy (SAA) is reported with isolated Sn atom embedded into the Cu lattice, as efficient ectrocatalyst for CO reduction. The as prepared SnCu-SAA catalyst shows a maximal C Faradaic efficiency of 79.

Mutagenesis and analysis of contrasting wheat lines do not support a role for PFT in Fusarium head blight resistance.

Ambiguity about whether the histidine-rich calcium-binding protein-coding gene (His) or the pore-forming toxin-like gene (PFT) or both are responsible for Fusarium head blight (FHB) resistance conferred by the Fhb1 quantitative trait locus hinders progress toward elucidating Fhb1 resistance mechanisms. Here, with a series of developed lines with or without PFT but all possessing His and five His-carrying PFT mutant lines created via gene editing, we show that PFT does not confer FHB resistance and that the His resistance effect does not require PFT in the tested conditions. We also show that PFT mutations are not associated with morphological and phenological characteristics that often affect FHB severity.

Exosomes-encapsulated biomimetic polydopamine carbon dots with dual-targeting effect alleviate motor and non-motor symptoms of Parkinson's disease via anti-neuroinflammation.

Currently, the clinical drugs for Parkinson's disease (PD) only focus on motor symptoms, while non-motor symptoms like depression are usually neglected. Even though, the efficacy of existing neurotherapeutic drugs is extremely poor which is due to the blood brain barrier (BBB). Therefore, a biomimetic polydopamine carbon dots (PDA C-dots) at 2-4 nm was synthesized, while exosomes from macrophages were applied to encapsulate PDA C-dots for improving their BBB-crossing ability and inflammation-targeting effect.