RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis.

Polycomb repressive complex 1 (PRC1) modifies chromatin through catalysis of histone H2A lysine 119 monoubiquitination (H2AK119ub1). RING1 and RNF2 interchangeably serve as the catalytic subunit within PRC1. Pathogenic missense variants in PRC1 core components reveal functions of these proteins that are obscured in knockout models.

Lack of pesticide toxicity to Echinostoma trivolvis eggs and miracidia.

Pesticides can elevate trematode infections in amphibians. However, direct adverse effects of pesticides on embryos and free-living stages of trematodes have not been thoroughly explored, despite the potential for these effects to reduce amphibian trematode infections. We measured the effects of atrazine, glyphosate, carbaryl, and malathion on embryo and miracidium (free-living stage) survival of Echinostoma trivolvis, a common trematode of amphibians.