Cognitive Remediation in Bipolar (CRiB2): study protocol for a randomised controlled trial assessing efficacy and mechanisms of cognitive remediation therapy compared to treatment as usual.

Background: A substantial proportion of people with bipolar disorder (BD) experience persistent cognitive difficulties associated with impairments in psychosocial functioning and a poorer disorder course. Emerging evidence suggests that cognitive remediation (CR), a psychological intervention with established efficacy in people with schizophrenia, can also benefit people with BD. Following a proof-of-concept trial showing that CR is feasible and potentially beneficial for people with BD, we are conducting an adequately powered trial in euthymic people with BD to 1) determine whether an individual, therapist-supported, computerised CR can reduce cognitive difficulties and improve functional outcomes; and 2) explore how CR exerts its effects.

The Mid-Pleistocene Transition: a delayed response to an increasing positive feedback?

Glacial-interglacial cycles constitute large natural variations in Earth's climate. The Mid-Pleistocene Transition (MPT) marks a shift of the dominant periodicity of these climate cycles from to  kyr. Recently, it has been suggested that this shift resulted from a gradual increase in the internal period (or equivalently, a decrease in the natural frequency) of the system.

Associations of sperm telomere length with semen parameters, clinical outcomes and lifestyle factors in human normozoospermic samples.

Background: Many studies have demonstrated that lifestyle factors can affect sperm quality and fertility. Sperm telomere length (STL) has been reported as potential biomarker or sperm quality. However, no studies have investigated how lifestyle factors can affect STL and associated clinical outcomes.

ATLAS: An advanced PCR-method for routine visualization of telomere length in Saccharomyces cerevisiae.

Measuring telomere length is essential in telomere biology. Southern blot hybridization is the predominant method for measuring telomere length in the genetic model Saccharomyces cerevisiae. We have further developed and refined a telomere PCR approach, which was rarely used previously (mainly in specific telomeric projects), into a robust method allowing direct visualisation of telomere length differences in routine experiments with S.

First hospital outbreak of the globally emerging in a European hospital.

Background: is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of in a London cardio-thoracic center between April 2015 and July 2016. This is the first report of in Europe and the largest outbreak so far.