Publications by authors named "J B Sexton"
Background: Globose neurofibrillary tangles (NFTs) are found in subcortical areas of post-mortem brain from individuals with the second most common primary tauopathy, progressive supranuclear palsy (PSP). The degree of cognitive impairment in secondary tauopathies such as Alzheimer's disease (AD) correlates with the presence of NFTs, which originally appear in the entorhinal cortex before spreading throughout the hippocampus. In contrast, the degree of hippocampal tau pathology in PSP is thought to be limited, consistent with the view that cognitive impairment in PSP is predominantly subcortical.
View Article and Find Full Text PDFObjective: Our primary objectives are to assess whether intraarticular corticosteroid injections are superior to saline injections with regards to thumb base pain after 4 weeks, and to compare the efficacy of steroid injections, saline injections, and an occupational therapy intervention on thumb base pain after 12 weeks in people with painful inflammatory osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint.
Design: In this three-armed, double-blind, randomized multicenter trial, 354 participants with painful inflammatory CMC-1 OA from six Norwegian hospitals are recruited. Participants are randomized 1:1:1 to intraarticular steroid or saline injections in the CMC-1 joint or a multimodal occupational therapy intervention.
Gestational Age-Specific Stillbirth Rates: Are We Using the Right Denominator?
Paediatr Perinat Epidemiol
December 2024
Article Synopsis
- Stillbirths happen globally every 17 seconds, leading to almost 2 million cases annually, and the common measure used, stillbirth rate, often overlooks important gestational age-specific trends.
- This study focused on analyzing stillbirth trends in Australia from 1998 to 2018, using three different methodologies to calculate stillbirth rates based on gestational age and risk: GS-SBR, FAR, and ccFAR.
- Results showed that the FAR and ccFAR measures provided a more accurate understanding of stillbirth risk as pregnancy progresses, highlighting distinct trends that could assist clinicians in their decision-making.
Background: As most people now have established hybrid immunity, the need for regular, updated SARS-CoV-2 vaccine boosters in patients with immune-mediated inflammatory diseases (IMIDs) is unclear. The study aim was to assess humoral and cellular immunogenicity of a fifth bivalent vaccine dose in patients with IMID on tumour necrosis factor inhibitors (TNFi).
Methods: In the longitudinal, observational Nor-vaC study, we assessed anti-spike and neutralising antibodies against Wuhan, Omicron BA.