Publications by authors named "J B Selvanayagam"
Background: There are limited data on the physical effects of androgen deprivation therapy (ADT) for prostate cancer (PC), and on the relationships of such measures of adiposity and strength to cardiovascular outcomes.
Objectives: The primary objective of this study was to evaluate the relationships of measures of adiposity and strength to cardiovascular outcomes (cardiovascular death, myocardial infarction, stroke, heart failure, arterial revascularization, peripheral arterial disease, and venous thromboembolism) in patients with PC. A secondary objective was to characterize the relationships between ADT use and 12-month changes in these physical measures.
Article Synopsis
- Vocalizations in nonhuman primates are crucial for daily interactions and might have influenced the development of human language.
- Research on the common marmoset has identified the anterior cingulate cortex (ACC) area 32 as part of the network for processing vocalizations, but its specific responses to sounds were previously unclear.
- Electrophysiological recordings show that about 50% of neurons in area 32 react to conspecific vocalizations and complex sounds, showing a unique pattern of initially decreased and then increased neural activity, indicating sound selectivity.
Article Synopsis
- The lateral prefrontal cortex in primates has distinct subregions with specialized functions, but understanding how these regions represent different sensory, social, and cognitive processes is still unclear.
- Previous studies have shown evidence of specialization, but findings are inconsistent due to variations in methods and tasks across different animals.
- By using the common marmoset for a detailed neurophysiological mapping, this study found that while some neuron responses are spread out across the cortex, responses related to specific tasks and stimuli are often localized to particular subregions.
Background And Aims: The detection of cancer therapy-related cardiac dysfunction (CTRCD) by reduction of left ventricular ejection fraction (LVEF) during chemotherapy usually triggers the initiation of cardioprotective therapy. This study addressed whether the same approach should be applied to patients with worsening of global longitudinal strain (GLS) without attaining thresholds of LVEF.
Methods: Strain surveillance during chemotherapy for improving cardiovascular outcomes (SUCCOUR-MRI) was a prospective multicentre randomized controlled trial involving 14 sites.