Widefield swept source optical coherence tomography for the monitoring of choroidal infiltrates.

Choroidal Infiltrates (Cis) detection is traditionally done using invasive imaging. We herein report the usage of topographic choroidal thickness maps (ChT maps) and en face swept-source Optical Coherence Tomography (OCT) as a rapid and non-invasive technique to monitor Cis in a patient with Chronic Lymphocytic Leukemia.

Polygons of quantized vortices in Bose-Einstein condensates with a circular trap.

We consider a disk-shaped cold atom Bose-Einstein condensate with repulsive atom-atom interactions within a circular trap, described by a two-dimensional time-dependent Gross-Pitaevskii equation with cubic nonlinearity and a circular box potential. In this setup, we discuss the existence of a type of stationary nonlinear waves with propagation-invariant density profiles, consisting of vortices located at the vertices of a regular polygon with or without an antivortex at its center. These polygons rotate around the center of the system and we provide approximate expressions for their angular velocity.

Cardiomyocyte infection by promotes innate immune response and glycolysis activation.

Introduction: Chagas cardiomyopathy, a disease caused by () infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for infection of human cardiomyocytes, the pathways activated during the acute phase of the disease, and the molecular changes that lead to the progression of cardiomyopathy.

Methods: To investigate the effects of on human cardiomyocytes during infection, we infected induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) with the parasite and analyzed cellular, molecular, and metabolic responses at 3 hours, 24 hours, and 48 hours post infection (hpi) using transcriptomics (RNAseq), proteomics (LC-MS), and metabolomics (GC-MS and Seahorse) analyses.

Energy- and time-controlled switching of ultrashort pulses in nonlinear directional plasmonic couplers.

We propose an ultracompact nonlinear plasmonic directional coupler for switching of ultrashort optical pulses. We show that this device can be used to control the routing of ultrashort pulses using either the energy or the duration of each individual pulse as switching parameters. The coupler is composed of two cores of a nonlinear dielectric material embedded into metallic claddings.

Mass Spectrometry Multiplexed Detection of SARS-CoV-2.

Testing of large populations for virus infection is now a reality worldwide due to the coronavirus (SARS-CoV-2) pandemic. The demand for SARS-CoV-2 testing using alternatives other than PCR led to the development of mass spectrometry (MS)-based assays. However, MS for SARS-CoV-2 large-scale testing have some downsides, including complex sample preparation and slow data analysis.