Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial.

Objective: To test if supplemental dietary selenium is associated with changes in the incidence of prostate cancer.

Patients And Method: A total of 974 men with a history of either a basal cell or squamous cell carcinoma were randomized to either a daily supplement of 200 microg of selenium or a placebo. Patients were treated for a mean of 4.

Salvage radical prostatectomy for adenocarcinoma of the prostate.

Radiotherapy has been a major method of treating localized carcinoma of the prostate. It is becoming increasingly apparent that failures of radiotherapy do occur and can be predicted by postradiation biopsy. Salvage radical prostatectomy can be offered to these patients.

Ultrasound detection of bilateral Leydig cell tumors in palpable normal testes.

We report a case of synchronous, nonpalpable, bilateral Leydig cell tumors that were detected only by ultrasound evaluation and gonadal vein sampling for estradiol. A review of the diagnostic and management options for Leydig cell tumors is presented.

Impact of routine screening for adenocarcinoma of the prostate on stage distribution.

The impact of routine screening with digital rectal examination for carcinoma of the prostate on stage distribution of the disease was assessed in the primary treatment population of our medical center. Two, 5-year periods were compared: 1974 to 1978--before the onset of routine screening and 1979 to 1983--during the period of routine screening of this population. The clinical stage distribution of prostatic cancer before the onset of routine screening was not significantly different from national averages.