Publications by authors named "J B Pinaquy"
Purpose: This analysis of the CIRSE Registry for SIR-Spheres Therapy in France, CIRT-FR, reports on real-world outcomes of transarterial radioembolisation (TARE) with Y90 resin microspheres for hepatocellular carcinoma (HCC) and colorectal cancer liver metastases (CRLM) patients in France, focusing on safety, effectiveness and health-related quality of life (HRQoL). Results on patients treated based on national reimbursement criteria are discussed here.
Methods: Prospective, multicentre, observational study of HCC and CRLM patients treated between August 2017 and July 2020 with TARE Y90 resin microspheres.
Article Synopsis
- - Hepatocellular carcinoma (HCC) is a major global health issue, being one of the most common cancers and a leading cause of cancer deaths, with intra-arterial therapies like TACE and SIRT being key treatment options for non-resectable cases.
- - TACE is typically used for patients with stage B HCC, while SIRT has shown promising results in patients previously treated with TACE, despite not having an official role in treatment guidelines.
- - A study involving 23 patients indicated that SIRT post-TACE resulted in a 73.8% objective response rate, with 56.5% achieving complete response, highlighting SIRT's potential effectiveness despite the complications associated with TACE.
Article Synopsis
- The study investigates the calculation of yttrium-90 microspheres activity essential for selective internal radiotherapy (SIRT).
- Using dosimetry software, researchers analyzed the absorbed doses to both tumors and healthy liver tissue before and after treatment phases.
- Results indicated significant correlations in dose distribution and suggested that optimizing microsphere dosages could enhance treatment effectiveness for some patients while reducing it for others.
Comparison of MRI-based response criteria and radiomics for the prediction of early response to transarterial radioembolization in patients with hepatocellular carcinoma.
Diagn Interv Imaging
July 2022
Purpose: The purpose of this study was to evaluate the capabilities of radiomics using magnetic resonance imaging (MRI) data in the assessment of treatment response to yttrium transarterial radioembolization (TARE) in patients with locally advanced hepatocellular carcinoma (HCC) by comparison with predictions based on European Association for the Study of the Liver (EASL) criteria.
Patients And Methods: Twenty-two patients with HCC (19 men, 3 women; mean age: 66.7 ± 9.