Publications by authors named "J B Ochieng"
Fetuin-A, also known as alpha-2-Heremans-Schmid-glycoprotein (Ahsg), is a multifunctional molecule with diverse roles in biological processes such as mineralization, tumor growth, and inflammation. This review explores the involvement of Ahsg in various cancers, including liver, breast, prostate, colorectal, brain, osteosarcoma, and lung cancers. In many cancer types, Ahsg promotes tumor growth, invasion, and metastasis through various mechanisms, including cellular adhesion, spreading, chemotaxis, and modulation of cell-growth signaling pathways.
View Article and Find Full Text PDFArticle Synopsis
- * A machine learning approach was applied using data from the VIDA and EFGH-Shigella studies in rural Kenya to create predictive models for LGF among children aged 6-35 months, encompassing 65 potential predictors including demographic and health-related factors.
- * The models showed a prevalence of LGF at 16.9% and 22.4% in different cohorts, with the gradient boosting model providing the best prediction accuracy, demonstrating its usefulness in identifying at-risk children for targeted healthcare interventions
Wesselsbron virus (WSLV) is a neglected mosquito-borne virus within the yellow fever subgroup in the genus of the family. Despite being primarily a veterinary pathogen able to cause stillbirths, congenital malformations, and mortality in ruminants, WSLV also infects humans, causing a usually self-limiting febrile illness, or may lead to neurological complications in rare cases. WSLV causes sporadic outbreaks in Southern Africa, but findings in mosquitoes from other African countries suggest a wider distribution.
View Article and Find Full Text PDFPro-inflammatory cytokines are secreted via the classical pathway from secretory vesicles or the non-classical pathway via extracellular vesicles (EVs), that together, play critical roles in triple-negative breast cancer (TNBC) progression. Annexin A6 (AnxA6) is a Ca -dependent membrane-binding protein that in TNBC is implicated in cell growth and invasiveness. AnxA6 is associated with EVs, but whether it affects the secretion of proinflammatory cytokines and/or EVs remains to be fully elucidated.
View Article and Find Full Text PDFArticle Synopsis
- Campylobacteriosis and antimicrobial resistance (AMR) are major global concerns, especially in Africa, which has the highest campylobacteriosis rates and significant AMR prevalence in Campylobacter spp. from humans and animals.
- A study analyzed 178 Campylobacter isolates (81 from human diarrheal patients in Kenya and 97 from poultry in Tanzania) between 2006-2017, using whole-genome sequencing and antimicrobial susceptibility testing.
- The findings revealed high sequence type diversity and noted that multidrug resistance was significantly higher in poultry (40.9%) compared to humans (2.5%), highlighting the need for better antimicrobial management in livestock.