A minority of Th1 and Tfh effector cells express survival genes shared by memory cell progeny that require IL-7 or TCR signaling to persist.

It is not clear how CD4 memory T cells are formed from a much larger pool of earlier effector cells. We found that transient systemic bacterial infection rapidly generates several antigen-specific T helper (Th)1 and T follicular helper (Tfh) cell populations with different tissue residence behaviors. Although most cells of all varieties had transcriptomes indicative of cell stress and death at the peak of the response, some had already acquired a memory cell signature characterized by expression of genes involved in cell survival.

Understanding the impact of delayed diagnosis and misdiagnosis of systemic lupus erythematosus (SLE).

Systemic lupus erythematosus (SLE) is a complex and multifaceted autoimmune disease that poses a significant diagnostic challenge for healthcare providers due to its diverse clinical manifestations, lack of specific testing, and potential to mimic other conditions. Delayed diagnosis and misdiagnosis of SLE can have serious consequences for patients, impacting their physical and psychological well-being. The physical consequences of delayed diagnosis and misdiagnosis of SLE are significant.

Characteristics of Patients Hospitalized With Methamphetamine-Associated Heart Failure: A Comparative Study of Enrolled vs Nonenrolled Patients.

Background: Methamphetamine-associated heart failure (MethHF) carries devastating individual and societal consequences; however, our understanding of this condition is limited.

Objective: The objective of this study is to compare the sociodemographic and clinical characteristics of patients hospitalized with MethHF with patients hospitalized with heart failure (HF) not associated with methamphetamine (non-MethHF).

Methods: This was an analysis of screening data from MethHF patients who screened out of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure study and a subset of non-MethHF patients enrolled in the study.

Integration of point of care ultrasound into undergraduate medical education at Texas Tech University Health Sciences Center school of medicine: a 6 year review.

Background: Point-of-care ultrasound (POCUS) education has become an essential component of medical school curricula. Ultrasound represents a highly effective teaching modality to reinforce anatomical knowledge gained during cadaveric dissections. At Texas Tech University Health Sciences Center-School of Medicine (TTUHSC-SOM), POCUS was incorporated into the pre-clerkship curriculum especially during the first year of medical school anatomy course.