Publications by authors named "J B Mear"

Objectives: Prompt HIV and STI diagnosis and treatment is a public health priority and relies on accessible testing. Technology-based approaches to distribute test kits have the potential to increase access to testing. We evaluated the acceptability and uptake of vending machines in publicly available settings in Brighton and Hove (BH) and Bristol, North Somerset and South Gloucestershire (BNSSG), to distribute HIV rapid self-test and STI self-sample kits.

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Background: Failure of gastrointestinal acute graft--host disease (GI-aGvHD) to respond to steroid therapy is associated with limited further therapeutic options. We aimed to assess the safety and efficacy of the first-in-human use of the pooled allogeneic faecal microbiota, MaaT013, for the treatment of steroid-refractory GI-aGvHD.

Methods: This prospective, international, single-arm, phase 2a study reports clinical outcomes from a 24-patient cohort with grade III-IV, steroid refractory GI-aGvHD treated with the pooled allogeneic faecal microbiota MaaT013.

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Article Synopsis
  • A multicentre retrospective study of 220 adult patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT) for therapy-related acute myeloid leukaemia (t-AML) reveals a median diagnosis age of 56 years and a significant history of prior hematological conditions or breast cancer.
  • At 12 months post-transplant, overall survival (OS) was 60.7%, event-free survival (EFS) was 52.8%, and graft-versus-host disease-free relapse-free survival (GRFS) was 44.1%; 44% of patients achieved complete remission by last follow-up.
  • The study indicates that uncontrolled t-AML at the time of transplant negatively impacts E
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Background: Vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic syndrome is a newly discovered inflammatory disease affecting male subjects, for which few data exist in the literature. Here, we describe the case of a patient with known Sweet's syndrome admitted to the intensive care unit and for whom a vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic syndrome was diagnosed, allowing for appropriate treatment and the patient's discharge and recovery.

Case Presentation: A 70-year-old male White patient was hospitalized in the intensive care unit following an intrahospital cardiac arrest.

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