High Expression of GPR183 Predicts Poor Survival in Cytogenetically Normal Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) with a normal karyotype (CN-AML) constitutes approximately 50% of all AML cases, presenting significant prognostic variability, and highlighting the urgent need for the identification of novel molecular biomarkers. In this study, we systematically assessed GPR183 expression levels using qRT-PCR in our clinical follow-up study which included 283 CN-AML patients. Using Kaplan-Meier analysis, we found that patients with high GPR183 expression levels exhibited significantly worse overall survival (OS) (P = 0.

Artificial liver support systems bridge severe immune-mediated hepatotoxicity to clinical recovery.

Background: The incidence of hepatic immune-related adverse events has increased with the wide use of immune checkpoint inhibitors, some immune-mediated hepatotoxicity cases are severe and lack of clinical recommendations.

Objective: This study aimed to evaluate the efficacy of artificial liver support systems (ALSS) in the treatment of immune-mediated hepatotoxicity.

Methods: This retrospective case series included six patients with grade 4 hepatotoxicity with high bilirubin induced by immune checkpoint inhibitors treated between January 1, 2019, to December 31, 2021.

Effect of cerium-zirconium oxide-loaded red mud on the selective catalytic reduction of NO in downhole diesel vehicle exhaust.

Red mud (RM), an iron oxide-rich solid waste, shows potential as a catalyst for selective catalytic reduction in denitrification processes. This study investigates the catalytic performance and mechanism of metal-modified RM in reducing NO from diesel vehicle exhaust. Acid-washed RM catalysts were impregnated with varying ratios of cerium (Ce) and zirconium (Zr).

Chemical proteomic profiling reveals prostaglandin termination enzyme PTGR2 as a key molecular target of natural coumarin fraxetin.

Natural coumarins represent a diverse group of secondary metabolites with a wide range of biological activities. However, their specific molecular targets have remained largely unexplored. Employing chemical proteomics, a comprehensive analysis of the protein targets of the natural coumarin fraxetin has been conducted.