Publications by authors named "J B Landes"
Background: Mitral annular disjunction (MAD), posterior displacement of the mitral valve leaflet hinge point, predisposes to arrhythmias or sudden cardiac death. We evaluated the burden of MAD, mitral valve prolapse (MVP), and mitral regurgitation (MR) by heritable thoracic aortic disease gene in a cross-sectional analysis of 2014-2023 data in the Montalcino Aortic Consortium registry.
Methods And Results: MAD was determined by direct measurement of echocardiographic images.
Article Synopsis
- - Tirbanibulin 1% ointment, approved by the EU in 2021, is used to treat actinic keratoses and has shown effectiveness against various HPV-related lesions and cancers.
- - A study on HeLa cells treated with tirbanibulin revealed that it inhibits cell proliferation with an IC of 31.49 nmol/L, downregulating multiple key proteins involved in cancer progression and cell cycle regulation.
- - The findings suggest that tirbanibulin affects HPV oncoprotein expression and activates apoptotic pathways, indicating a potential mechanism for its antiproliferative effects.
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with high rates of metastasis and mortality. In vitro studies suggest that selinexor (KPT-330), an inhibitor of exportin 1, may be a targeted therapeutic option for MCC. This selective inhibitor prevents the transport of oncogenic mRNA out of the nucleus.
View Article and Find Full Text PDFMethods: 30 male patients with primary inguinal hernias undergoing primary inguinal herniorrhaphy were prospectively recruited for ilioinguinal nerve resection and evaluation. Three samples of the resected ilioinguinal nerve (proximal, canal, and distal) were evaluated using Masson's trichrome stain to measure fascicle and total nerve cross-sectional area and detect changes in collagen.
Results: The fascicle cross-sectional area in the canal segment was significantly decreased compared to the proximal control with a large effect size observed ( = 0.