Publications by authors named "J B Kovacs"
Background: Lymph node upstaging represents a quality criterion for standardized lymphadenectomy in lung cancer surgery. The aim of the study was to compare whether the quality of standardized lymphadenectomy in lung cancer surgery is comparable in minimally invasive (video-assisted thoracoscopic surgery) and the open approach (thoracotomy). Furthermore, factors associated with lymph node upstaging were assessed, as was its impact on overall survival and progression-free survival.
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- Respecting patient autonomy is essential in medicine, but can clash with the principles of beneficence (doing good) and nonmaleficence (doing no harm), especially in complex cases like oral health care.
- The study analyzed scholarly articles to understand how this ethical conflict arises and how it has been addressed in clinical scenarios, particularly in maxillofacial treatments.
- The results showed that while most recommendations leaned towards prioritizing medical benefits for the patient, there were also instances where patient autonomy was upheld, particularly for preventive care or low-impact interventions.
Article Synopsis
- HLA mismatches between lung transplant donors and recipients can lead to the formation of donor-specific antibodies, particularly HLA-DQ-dnDSA, which can negatively affect transplant outcomes.
- The study analyzed data from 183 lung transplant patients from 2012 to 2020, finding that 22.9% developed HLA-DQ-dnDSA, with homozygous HLA-DQ patients at a higher risk compared to heterozygous patients.
- The research identified specific HLA-DQ combinations and eplets that increase the risk for dnDSA development, suggesting that improving immunological compatibility could enhance graft outcomes.
Background: Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma proteome.
Methods: PCR-positive SARS-CoV-2 patients, enrolled in a natural history study, underwent analysis of the plasma proteome. A prospective cohort of 66 unvaccinated and 24 vaccinated persons with different degrees of infection severity were evaluated acutely (within 40 days of symptom onset), and at three and ten months.
Background: Local ablative therapies (LAT) are increasingly used in patients with metastatic soft tissue sarcoma (STS), yet evidence-based standards are lacking. This study aimed to assess the impact of LAT on survival of metastatic STS patients and to identify prognostic factors.
Methods: In this retrospective multicenter study, 246 STS patients with metastatic disease who underwent LAT on tumor board recommendation between 2017 and 2021 were analyzed.