Sleep Health and Falls Risk for Older Adults Living in Residential Aged Care and in Community Dwelling Settings: A Longitudinal Observation Study.

This study explored measures of subjective and objective sleep health and the association with fall occurrence and falls risk for older adults. A longitudinal observational study was conducted with participants in residential aged care (n = 36) and community dwelling (n = 35) settings. At baseline, objective sleep data involved wearing wrist worn accelerometers and measuring falls risk by walking using the Quantitative timed up and go (QTUG) of a simple, cognitive, and motor task.

Changes in the force-time curve during a repeat power ability assessment using loaded countermovement jumps.

Background: Repeat power ability (RPA) assessments traditionally use discrete variables, such as peak power output, to quantify the change in performance across a series of jumps. Rather than using a discrete variable, the analysis of the entire force-time curve may provide additional insight into RPA performance. The aims of this study were to (1) analyse changes in the force-time curve recorded during an RPA assessment using statistical parametric mapping (SPM) and (2) compare the differences in the force-time curve between participants with low and high RPA scores, as quantified by traditional analysis.

Gender challenges within the UK Defence Medical Services: recruiting and retaining a diverse workforce.

While there are women represented in some notable positions within the UK Defence Medical Services (DMS), the challenges and barriers to successful female progression have not disappeared. The DMS needs highly talented, motivated doctors working to support operations, yet we struggle to recruit and retain female personnel. This is in clear contrast to the increased proportion of female personnel working within the civilian medical workforce.

Morphological evolution and niche conservatism across a continental radiation of Australian blindsnakes.

Understanding how continental radiations are assembled across space and time is a major question in macroevolutionary biology. Here, we use a phylogenomic-scale phylogeny, a comprehensive morphological dataset, and environmental niche models to evaluate the relationship between trait and environment and assess the role of geography and niche conservatism in the continental radiation of Australian blindsnakes. The Australo-Papuan blindsnake genus, Anilios, comprises 47 described species of which 46 are endemic to and distributed across various biomes on continental Australia.

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.

Protein Tyrosine Phosphatase 1B (PTP1B) is a negative regulator of leptin signaling whose disruption protects against diet-induced obesity in mice. We investigated whether structural characterization of human PTP1B variant proteins might reveal precise mechanisms to target for weight loss therapy. We selected 12 rare variants for functional characterization from exomes from 997 people with persistent thinness and 200,000 people from UK Biobank.