Publications by authors named "J B Justice"
Immune checkpoint inhibition of metastatic melanoma: achieving high efficacy in the face of high toxicity.
Expert Rev Clin Pharmacol
November 2024
Introduction: Immune checkpoint inhibitors (ICIs) have advanced the treatment of metastatic melanoma by blocking immune system down-regulators enhancing T-cell-mediated anti-tumor responses. However, many ICIs induce immune-related adverse effects (irAEs) that can impact many organ systems.
Areas Covered: Strategies used to manage irAEs include corticosteroids, anti-tumor necrosis factor alpha (TNF-α) agents, other biological therapies, fecal microbiota transplantation (FMT), and emerging regimens.
The short-wave infrared range is highly significant for spectroscopic sensing and upcoming optical communication applications. Integrating active and passive photonic components is essential to achieve compact optical solutions. In this paper, we show, for the first time to our knowledge, a wavelength-selective detection system based on the heterogeneous integration of two grating-coupled InGaAs photodetectors operating at the 2µm wave band, with a wavelength selectivity provided by a dual-channel Mach-Zehnder interferometer fabricated using a silicon-on-insulator (SOI) wafer.
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- - The study investigates how weight loss affects aging-related biological markers (specifically SASP) in older adults with obesity, using a six-month telemedicine weight loss program for participants aged 65 and older with a BMI of 30 kg/m or more.
- - Participants who successfully lost at least 5% of their body weight showed significant improvements in physical function and other health markers, with specific SASP cytokines showing strong associations with their outcomes.
- - The results suggest that intentional weight loss may enhance functional abilities in older adults, but further research with randomized trials is needed to confirm these findings and explore additional biomarkers.
Article Synopsis
- The study examines the preoperative olfactory function in patients undergoing endoscopic skull base surgery (ESBS) and functional endoscopic sinus surgery (FESS), highlighting a knowledge gap compared to FESS assessments.
- It analyzed data from 171 patients, revealing that only 57% accurately reported their preoperative olfactory function, with a notable discrepancy between actual hyposmia and patient reports, particularly in those undergoing ESBS.
- The findings point to a significant underreporting of olfactory issues in ESBS patients and discrepancies in the FESS cohort, suggesting a need for more thorough olfactory testing to improve prognostic certainty and address medicolegal concerns.
Article Synopsis
- Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
- The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
- The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*