Publications by authors named "J B Holter"
Patients with Inflammatory Bowel Disease (IBD) undergoing immunosuppressive therapies face heightened susceptibility to severe COVID-19. An in-depth understanding of systemic inflammation and cellular immune responses after SARS-CoV-2 vaccination and breakthrough infections (BTI) is required for optimizing vaccine strategies in this population. While the prevalence of high serological responders post- third COVID-19 vaccine dose was lower, and the antibody waning was higher in IBD patients than in healthy donors (HD), IBD patients showed an increase in anti-RBD Wild Type IgG levels and cross-reactive Spike -specific memory B cells following BTI.
View Article and Find Full Text PDFArticle Synopsis
- * A study analyzed data from 2002 to 2021, showing a significant increase in mortality rates among children in rural regions, with the most rural group experiencing a 2.4 times higher risk of fatal injuries.
- * The findings indicate that most paediatric deaths occurred before reaching a hospital, particularly among older teens, with transport-related injuries being the leading cause, highlighting the need for targeted prevention efforts in rural areas.
Article Synopsis
- A study investigated the global prevalence of Long Covid symptoms in individuals from high-income countries (HICs) and low- to middle-income countries (LMICs), since most previous research focused on HICs.
- The research involved 11,860 participants from 17 countries, examining symptoms like fatigue, breathlessness, and their impact on daily life at various time points after hospitalization.
- Findings revealed a significantly higher proportion of Long Covid cases and associated symptoms in HICs compared to LMICs, suggesting that while LMICs have lower reported rates, the overall impact of Long Covid might still be significant due to healthcare disparities.
Blood and lymphatic vessels in the body are central to molecular and cellular transport, tissue repair, and pathophysiology. Several approaches have been employed for engineering microfabricated blood and lymphatic vessels , yet traditionally these approaches require specialized equipment, facilities, and research training beyond the capabilities of many biomedical laboratories. Here we present xurography as an inexpensive, accessible, and versatile rapid prototyping technique for engineering cylindrical and lumenized microvessels.
View Article and Find Full Text PDFThe COVID-19 pandemic posed a challenge for people living with HIV (PLWH), particularly immune non-responders (INR) with compromised CD4 T-cell reconstitution following antiretroviral therapy (CD4 count <350 cells per mm). Their diminished vaccine responses raised concerns about their vulnerability to SARS-CoV-2 breakthrough infections (BTI). Our in-depth study here revealed chronic inflammation in PLWH and a limited anti-Spike IgG response after vaccination in INR.
View Article and Find Full Text PDF