Safety Assessment of Graphene-Based Materials.

Graphene is the first 2D atomic crystal, and its isolation heralded a new era in materials science with the emergence of several other atomically thin materials displaying multifunctional properties. The safety assessment of new materials is often something of an afterthought, but in the case of graphene, the initial isolation and characterization of the material was soon followed by the assessment of its potential impact on living systems. The Graphene Flagship project addressed the health and environmental aspects of graphene and other 2D materials, providing an instructive lesson in interdisciplinarity - from materials science to biology.

Formation of mono- and dual-labelled antibody fragment conjugates reversible site-selective disulfide modification and proximity induced lysine reactivity.

Many protein bioconjugation strategies focus on the modification of lysine residues owing to the nucleophilicity of their amine side-chain, the generally high abundance of lysine residues on a protein's surface and the ability to form robustly stable amide-based bioconjugates. However, the plethora of solvent accessible lysine residues, which often have similar reactivity, is a key inherent issue when searching for regioselectivity and/or controlled loading of an entity. A relevant example is the modification of antibodies and/or antibody fragments, whose conjugates offer potential for a wide variety of applications.

Impact of worklist selection on point-of-care ultrasound workflow - a quality improvement project.

Background: Research demonstrates that Point-of-care ultrasound (POCUS) improves clinical outcomes for patients. Improving clinician satisfaction with POCUS should promote utilization into everyday practice, leading to improved clinical outcomes. Despite this benefit, there are still barriers to use including POCUS workflow.

Addressing the Shortage of Academic Nurse Educators: An Opportunity for Collaboration Between Academic and Healthcare Organization Leaders.

Background: The numbers of nursing school admissions and, thus, future nursing graduates are directly affected by the lack of qualified ANEs.

Methods: A consortium of diverse ANEs was formed to research these questions using the nominal group technique.

Results: Two central themes emerged from the consortium: support and collaboration.

Ethnic disparities in rapid tranquillisation use and justifications in adult mental health inpatient settings: a systematic review and meta-analysis.

Question: Evidence on the likelihood of receiving rapid tranquillisation (RT) across ethnic groups is mixed, with some studies suggesting that ethnic minorities are more likely to receive RT than others. We aimed to investigate the association between ethnicity and RT use in adult mental health inpatient settings and to explore explanations for RT use in relation to ethnicity.

Study Selection And Analysis: We searched six databases, grey sources, and references from their inception to 15 April 2024.