Publications by authors named "J B Guy"
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) and is a leading non-traumatic cause of disability in young adults. The 18 kDa Translocator Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly expressed in MS brain lesions. It is used as an inflammatory biomarker and has been proposed as a therapeutic target.
View Article and Find Full Text PDFObjective: Pharmacologic thrombolytic treatment for acute ischemic stroke has primarily been managed by intravenous alteplase. Tenecteplase is a variant that has been shown to be non-inferior to alteplase in clinical trials. In this study, we present a real-world assessment of patient outcomes with the facility-wide transition to the use of tenecteplase versus altepase for acute ischemic stroke in a large system of community hospitals in the United States.
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- Preterm birth (PTB) is a major cause of complications in newborns, and identifying women at risk for spontaneous preterm labor (PTL) is difficult due to the lack of reliable diagnostic tools.
- The study investigated the link between specific maternal lymphocyte subpopulations and the likelihood of giving birth within 7 days for women hospitalized with PTL between 24 and 34 weeks of pregnancy.
- Results indicated that higher levels of certain lymphocyte markers were associated with a higher likelihood of delivering soon, allowing for the potential identification of high-risk women and possibly reducing unnecessary hospital admissions and related healthcare costs if confirmed in future research.
Purpose: Cluster of differentiation 40 (CD40) is expressed on B-cell acute lymphoblastic leukemia (B-ALL) cases. However, the effect of CD40 activation on B-ALL cells has never been tested in vivo.
Experimental Design: The aim of our preclinical study was to investigate the therapeutic potential of a CD40 agonist in the treatment of B-ALL using patient-derived xenograft mouse models.
Objective: To assess the feasibility of a pilot pharmacogenomics concierge service that incorporates student practice-based learning opportunities and a survey to determine the patients' interest and willingness to pay.
Methods: Participants in the pilot study (n = 34) completed a survey to determine their willingness to pay for concierge services. Six participants indicating the highest level of interest were selected to participate in the program free of charge.