Publications by authors named "J B Grogan"
Motivation depends on dopamine, but might be modulated by acetylcholine which influences dopamine release in the striatum, and amplifies motivation in animal studies. A corresponding effect in humans would be important clinically, since anticholinergic drugs are frequently used in Parkinson's disease, a condition that can also disrupt motivation. Reward and dopamine make us more ready to respond, as indexed by reaction times (RT), and move faster, sometimes termed vigour.
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- ALS is a fast-progressing neurodegenerative disease with no cure and limited treatment options, creating a need for better therapies.
- A study was conducted to examine the effects of memantine on ALS progression and related cognitive and behavioral changes using a randomized, placebo-controlled trial with 89 participants.
- Results showed that memantine did not significantly affect the progression of ALS, biomarker changes, or neuropsychiatric symptoms compared to a placebo.
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- Neisseria gonorrhoeae causes a common STI that can range from mild symptoms to severe complications like pelvic inflammatory disease and septic arthritis.
- A young woman initially presented with fever and joint pain, leading to a diagnosis of inflammatory arthritis following immune suppressing treatments, which resulted in further neurological symptoms and muscle issues.
- Testing revealed a positive urine gonorrhoeae PCR and septic arthritis; she was treated with antibiotics but showed only slow, incomplete recovery.
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- Pro-inflammatory immune responses are suppressed during blood-stage malaria, but the specific molecular mechanisms behind this are not fully clear.
- This study reveals that the co-inhibitory receptors TIGIT and PD-1 are increased in certain T cells during a non-lethal malaria infection.
- Blocking both TIGIT and PD-L1 together leads to better parasite control and heightened production of key immune signaling molecules, suggesting these receptors play a crucial role in managing the body's immune response during malaria infection.