Publications by authors named "J B Grimm"
Article Synopsis
- Research indicates significant sex differences in addiction behaviors, with females showing a higher motivation to consume sucrose than males.
- The study utilized a progressive ratio schedule to assess motivation for 10% sucrose after different periods of environmental enrichment, revealing that acute and chronic enrichment reduced breakpoints for males more persistently than for females.
- Both sexes exhibited increased motivation to consume after 29 days of abstinence, but environmental enrichment had a less significant impact on females compared to males, highlighting the need for gender-focused approaches in addiction research.
Article Synopsis
- The study explores how tumors develop their own blood supply (neovasculature) using advanced microfluidic technology to co-culture cancer spheroids and endothelial cells.
- This model showcases the interaction between metastatic renal cell carcinoma and blood vessels, highlighting how tumors can prompt blood vessel growth toward themselves.
- The research also evaluates the effects of bevacizumab, an antiangiogenic therapy, demonstrating its potential to impair tumor-induced blood vessel formation in real-time observation.
Neurochemical signals like dopamine (DA) play a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex networks has been hindered by the challenge of detecting multiple neurochemicals simultaneously. To overcome this limitation, we developed a single-protein chemigenetic DA sensor, HaloDA1.
View Article and Find Full Text PDFDental enamel is subjected to a lifetime of de- and re-mineralization cycles in the oral environment, the cumulative effects of which cause embrittlement with age. However, the understanding of atomic scale mechanisms of dental enamel aging is still at its infancy, particularly regarding where compositional differences occur in the hydroxyapatite nanocrystals and what underlying mechanisms might be responsible. Here, we use atom probe tomography to compare enamel from a young (22 years old) and a senior (56 years old) adult donor tooth.
View Article and Find Full Text PDFFerroptosis emerged as a cell death modality for drug resistant cancer cells, but there are currently no available biomarkers for imaging ferroptosis based therapies. To address this gab, we evaluated the nanodynamic changes in lipid membranes occurring during cell death to explore potential targeting opportunities to image cell death. We nano-sized gaps at late stages of ferroptosis can serve as entry points for dyes that can bind to cellular structures.
View Article and Find Full Text PDF