Molecular and spatial analysis of tertiary lymphoid structures in Sjogren's syndrome.

Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial relationship remain unknown. Here we use combine single-cell RNA-sequencing, spatial transcriptomics and proteomics of minor salivary glands of patients with Sjogren's disease and Sicca Syndrome, with ex-vivo functional studies to construct a cellular and spatial map of key components involved in the formation and function of tertiary lymphoid structures.

Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study.

Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in a multisite case-control cohort study of Chinese women with recurrent depression.

Using Animal Welfare Framing as an Effective Approach to Communicating Climate Change-A Review.

Introduction: Climate change and its effects continue to threaten the stability of environments worldwide, impacting nearly every species. Although framing is an established technique in climate communication science, little has been done in communicating the climate change effects from an animal welfare perspective.

Objectives: The primary objective of this article is to present the synthesis of evidence in existing literature on the effects of communicating climate change as an animal welfare issue.

ASSESSMENT OF OPHTHALMIC DIAGNOSTIC PARAMETERS, CONJUNCTIVAL FLORA, AND PHARMACOLOGIC DILATION OF A LARGE POPULATION OF JUVENILE AMERICAN ALLIGATORS ().

American alligators () are an important apex predator of semiaquatic habitats of the southern United States. Commercial alligator farming has grown in the last several decades, leading to a need to understand the health conditions that affect this species to ensure appropriate management and welfare. The aims of this study were 1) to establish and describe normative data including results of common ophthalmic diagnostic tests and conjunctival flora, 2) document ocular pathology in this population, and 3) assess the effect of topical rocuronium bromide and 10% phenylephrine for facilitating pharmacologic mydriasis.