Publications by authors named "J B Dumond"
A Cross-Biomeasure Study to Optimize Antiretroviral Adherence Estimation.
J Acquir Immune Defic Syndr
November 2024
Background: Incomplete adherence to daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) reduces effectiveness. Adherence biomeasures (i.e.
View Article and Find Full Text PDFArticle Synopsis
- A study investigated long-term body weight changes in people with HIV (PWH) who switched to antiretroviral therapies containing integrase strand-transfer inhibitors (INSTIs), comparing them with those on non-INSTI therapies and people without HIV (PWOH).
- The analysis included 3464 participants and revealed that women experienced significantly greater weight gain and increases in hip and thigh circumference after switching to INSTIs compared to men, with women gaining +3.0 kg and men +1.8 kg over 5 years.
- The findings suggest a 2-fold higher weight change in women versus men following the switch to INSTIs, although the long-term health implications of this difference are still uncertain.
Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals.
Clin Pharmacol Ther
February 2025
The mainstay of antiretroviral therapy (ART) has been combination oral therapy. While oral ART is highly effective, nonadherence remains a chief concern. Addressing this concern in recent years is the emergence of long-acting antiretrovirals for the treatment and prevention of HIV-1 infection.
View Article and Find Full Text PDFBackground: Situated within a larger project entitled "Exploring the Need for a Uniquely Different Approach in Northern Ontario: A Study of Socially Accountable Artificial Intelligence," this rapid review provides a broad look into how social accountability as an equity-oriented health policy strategy is guiding artificial intelligence (AI) across the Canadian health care landscape, particularly for marginalized regions and populations. This review synthesizes existing literature to answer the question: How is AI present and impacted by social accountability across the health care landscape in Canada?
Methodology: A multidisciplinary expert panel with experience in diverse health care roles and computer sciences was assembled from multiple institutions in Northern Ontario to guide the study design and research team. A search strategy was developed that broadly reflected the concepts of social accountability, AI and health care in Canada.
Background: Broadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, a CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention efficacy against highly neutralization-sensitive viruses but was ineffective against less sensitive viruses. VRC07-523LS is a next-generation bnAb targeting the CD4-binding site and was engineered for increased neutralization breadth and half-life.
View Article and Find Full Text PDF