Publications by authors named "J B Derbyshire"
Incorporation of the central vein sign into the McDonald criteria.
Mult Scler Relat Disord
November 2024
Background: Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.
Objective: Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.
Adequate fruit and vegetable consumption is essential for healthy ageing and prevention and management of chronic disease. This study aimed to examine characteristics associated with fruit and vegetable consumption in Chinese men and women aged 50 years and over. Data from the first wave of the Chinese cohort (2008-2010) of the WHO's Study on global AGEing and adult health (SAGE) survey was used.
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- Extreme events like the credit crunch and the COVID-19 pandemic share the theme that they were unexpected despite prior warnings or signs.
- Risk assessments often fail because they only account for known factors, leaving unknown uncertainties unaddressed.
- The article advocates for incorporating "unknowledge" into risk assessment frameworks, encouraging assessors to recognize and evaluate what they don't know to better prepare for surprises.
Article Synopsis
- The central vein sign (CVS) is a proposed biomarker for diagnosing multiple sclerosis (MS) but traditional manual ratings for assessing CVS lesions can be slow and inconsistent.
- This study compared an automated CVS detection method to manual rating in 86 participants being evaluated for MS using 3T MRI scans.
- Results showed the automated method had a similar effectiveness in distinguishing MS patients from non-patients as the manual methods, with an area under the curve (AUC) ranging between 0.78 and 0.89, depending on the method used.
Article Synopsis
- The study evaluates the effectiveness of simplified imaging methods (central vein sign or CVS) compared to cerebrospinal fluid oligoclonal bands (OCB) as diagnostic tools for multiple sclerosis (MS).
- Results indicate that both methods have similar sensitivity and specificity, with a higher positive predictive value (PPV) for the CVS method after 12 months.
- Further research is planned to determine if CVS can replace or work alongside OCB for diagnosing MS.