Leveraging Accountable Care Organization infrastructure for rapid pandemic response in independent primary care practices.

Background: Population risk segmentation and technology-enabled preventive care workflows are core competencies for Accountable Care Organizations (ACOs) that may also have relevance for public health emergencies.

Methods: During the early weeks of the COVID-19 pandemic, we aimed to leverage existing ACO capabilities to support 467 primary care practices across 27 states with pandemic response. We used Medicare claims and electronic health records to identify patients with increased COVID-19 vulnerability, for proactive outreach and guidance for "Staying Well at Home.

Endoscopic sinus surgery in patients older than sixty.

Objective: Rhinosinusitis is the sixth most common chronic condition of the elderly. Functional endoscopic sinus surgery (FESS) has developed over the last 20 to 30 years into a widely accepted treatment modality for chronic rhinosinusitis in adults who have failed maximal medical management. The aim of this study was investigate the safety and efficacy of FESS in the geriatric population as compared to that of the adult population.

Transduction and adaptation in sensory hair cells of the mammalian vestibular system.

The human vestibular apparatus detects head movements and gravitational stimuli which impinge upon the mechanosensory hair cells of the inner ear. The hair cells, in turn, transduce these stimuli into electrical signals which are transmitted to the brain. These sensory cells are exquisitely responsive, signaling deflections of their mechanosensitive organelles as small as 1-2 nanometers.

Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases.

Breast cancer cell lines vary in invasive behavior and one highly invasive cell line (MDA-MB-231) proteolytically degrades extracellular matrix with invadopodia (Thompson et al. 1992, J Cell Physiol, 150, 534-44; Chen et al 1994, Breast Cancer Res Treat, 31, 217-26). Invadopodial proteolysis of extracellular matrix is thought to be necessary for invasion; however, this has not been demonstrated directly.

Endoscopic sinus surgery. A 300 case review.

The introduction of ESS (endoscopic sinus surgery) has changed and vastly improved the potential of sinus surgery. It is now possible to visualize obstruction in the natural sinus ostia and remove diseased tissue, thereby promoting restoration of normal function. A series of 300 consecutively performed cases is reviewed; results and complications are reported.