Emergence and Rising Prevalence of Artemisinin Partial Resistance Marker Kelch13 P441L in a Low Malaria Transmission Setting in Southern Zambia.

Increasing artemisinin partial resistance (ArtR) due to mutations in the gene encoding Kelch13 ( ) protein in eastern Africa is of urgent concern, and mutations, such as P441L, continue to emerge. We used an amplicon deep-sequencing panel to estimate the prevalence of ArtR mutations in samples collected between 2018 and 2023 in southern Zambia. P441L was present in 30 of 501 samples (6%), and prevalence increased over time (0% to 7.

Multiple plastid losses within photosynthetic stramenopiles revealed by comprehensive phylogenomics.

Ochrophyta is a vast and morphologically diverse group of algae with complex plastids, including familiar taxa with fundamental ecological importance (diatoms or kelp) and a wealth of lesser-known and obscure organisms. The sheer diversity of ochrophytes poses a challenge for reconstructing their phylogeny, with major gaps in sampling and an unsettled placement of particular taxa yet to be tackled. We sequenced transcriptomes from 25 strategically selected representatives and used these data to build the most taxonomically comprehensive ochrophyte-centered phylogenomic supermatrix to date.

Maternal perinatal anxiety and infant primary care use in 1998-2016: a UK cohort study.

Background: There is some evidence that perinatal anxiety (PNA) is associated with lower rates of infant vaccinations and decreased access to preventative infant healthcare, but results across studies have not been conclusive.

Objective: To investigate the relationship between maternal PNA and infant primary care use.

Methods: Cohort study of mother-infant pairs identified between 1998 and 2016 using IQVIA Medical Research Database (IMRD).

Historical Redlining and Community-Reported Housing Quality: A Spatial Analysis.

Historical redlining, a racially discriminatory practice implemented by the US government in the 1930s, has been associated with present-day environmental outcomes. However, there is limited research examining the relationship between historical redlining and contemporary housing quality. The objective of the present study was to investigate the relationship between historical redlining and contemporary housing quality in Atlanta, Georgia.